| Date | Location | Result | |
| Dec 11, 2010 | Cleveland, Miss. | Delta State (MS) 29, Shepherd 17 | Box score |
| Dec 04, 2010 | Mercyhurst | Shepherd 49, Mercyhurst (PA) 14 | Box score |
| Nov 27, 2010 | Kutztown, PA | Shepherd 41, Kutztown (PA) 34 | Box score |
| Nov 20, 2010 | Shepherdstown, WV | Shepherd 40, Shaw (NC) 6 | Box score |
| Nov 13, 2010 | Fairmont, W.Va. | Fairmont State 63, W.Va. State 38 | Box score |
| Nov 13, 2010 | Athens, WV | West Liberty 56, Concord 33 | Box score |
| Nov 13, 2010 | Buckhannon, WV | W.Va. Wesleyan 41, Charleston 21 | Box score |
| Nov 13, 2010 | Shpherdstown, WV | Glenville State 28, Shepherd 24 | Box score |
| Nov 06, 2010 | Greensburg, PA | West Liberty 82, Seton Hill 36 | Box score |
| Nov 06, 2010 | Princeton, WV | Concord 41, Fairmont State 17 | Box score |
| Nov 06, 2010 | Institute, WV | W.Va. Wesleyan 50, W.Va. State 28 | Box score |
| Nov 06, 2010 | Glenville, WV | Charleston 44, Glenville State 16 | Box score |
| Oct 30, 2010 | Pembroke, N.C. | Concord 30, UNC Pembroke 26 | Box score |
| Oct 30, 2010 | West Liberty, WV | West Liberty 37, Charleston 23 | Box score |
| Oct 30, 2010 | Fairmont, W.Va. | Fairmont State 44, Seton Hill 29 | Box score |
| Oct 30, 2010 | Buckhannon,WV | W.Va. Wesleyan 31, Glenville State 24 | Box score |
| Oct 30, 2010 | Institute, WV | Shepherd 56, W.Va. State 19 | Box score |
| Oct 23, 2010 | Glenville, WV | Glenville State 42, W.Va. State 27 | Box score |
| Oct 23, 2010 | Urbana, OH | Charleston 44, Urbana (OH) 34 | Box score |
| Oct 23, 2010 | Greensburg, PA | Concord 28, Seton Hill 17 | Box score |
| Oct 23,2010 | West Liberty, WV | Shepherd 53, West Liberty 38 | Box score |
| Oct 23, 2010 | Fairmont, W.Va. | Fairmont State 45, W.Va. Wesleyan 14 | Box score |
| Oct 16, 2010 | Pembroke, N.C. | UNC Pembroke 24, Fairmont State 0 | Box score |
| Oct 16, 2010 | Charleston, WV | Charleston 24, Seton Hill 20 | Box score |
| Oct 16, 2010 | Shepherdstown, WV | Shepherd 37, W.Va. Wesleyan 26 | Box score |
| Oct 16, 2010 | Athens, WV | Concord 49, Glenville State 14 | Box score |
| Oct 16, 2010 | Institute, WV | West Liberty 48, W.Va. State 26 | Box score |
| Oct 09, 2010 | Salisbury, NC | W.Va. Wesleyan 58, Livingstone (NC) 3 | Box score |
| Oct 09, 2010 | Charleston, WV | Charleston 35, Fairmont State 27 | Box score |
| Oct 09, 2010 | Greensburgh, PA | Seton Hill 48, W.Va. State 20 | Box score |
| Oct 09, 2010 | West Liberty, WV | West Liberty 47, Glenville State 21 | Box score |
| Oct 09, 2010 | Shepherdstown, WV | Shepherd 49, Concord 35 | Box score |
| Oct 02, 2010 | Glenville, WV | UNC Pembroke 28, Glenville State 14 | Box score |
| Oct 02, 2010 | Charleston, WV | Shepherd 28, Charleston 13 | Box score |
| Oct 02, 2010 | Institute, WV | Concord 42, W.Va. State 18 | Box score |
| Oct 02, 2010 | Buckhannon, WV | W.Va. Wesleyan 37, Seton Hill 16 | Box score |
| Sep 30, 2010 | Fairmont, W.Va. | West Liberty 43, Fairmont State 23 | Box score |
| Sep 25, 2010 | Greensburg, PA | Shepherd 46, Seton Hill 17 | Box score |
| Sep 25, 2010 | West Liberty, WV | W.Va. Wesleyan 43, West Liberty 41 | Box score |
| Sep 25, 2010 | Athens, WV | Concord 37, Charleston 28 | Box score |
| Sep 25, 2010 | Glenville, WV | Glenville State 17, Fairmont State 14 | Box score |
| Sep 18, 2010 | Charleston, WV | Charleston 42, W.Va. State 0 | Box score |
| Sep 18, 2010 | Shepherdstown, WV | Shepherd 19, Fairmont State 16 | Box score |
| Sep 18, 2010 | Buckhannon, WV | W.Va. Wesleyan 20, Concord 13 | Box score |
| Sep 18, 2010 | Glenville, WV | Glenville State 38, Seton Hill 28 | Box score |
| Sep 11, 2010 | New Haven, Conn. | West Liberty 49, Southern Connecticut 35 | Box score |
| Sep 11, 2010 | Ettrick, VA | Virginia State 34, W.Va. State 21 | Box score |
| Sep 11, 2010 | Urbana, Ohio | Urbana (OH) 44, Seton Hill 13 | Box score |
| Sep 11, 2010 | Fairmont, W.Va. | Fairmont State 38, Notre Dame (OH) 0 | Box score |
| Sep 11, 2010 | Shepherdstown, WV | Shepherd 55, Saint Joseph's (IN) 0 | Box score |
| Sep 11, 2010 | Glenville, WV | North Alabama 54, Glenville State 10 | Box score |
| Sep 04, 2010 | Greensburg, PA | New Haven (CT) 34, Seton Hill 17 | Box score |
| Sep 04, 2010 | Hickory, N.C. | Concord 20, Lenoir-Rhyne (NC) 17 | Box score |
| Sep 04, 2010 | Dayton, OH | Central State (OH) 34, W.Va. State 14 | Box score |
| Sep 04, 2010 | West Liberty, WV | Edinboro (PA) 20, West Liberty 19 | Box score |
| Sep 04, 2010 | Charleston, WV | Charleston 42, Mars Hill (NC) 20 | Box score |
| Sep 04, 2010 | Buckhannon, WV | W.Va. Wesleyan 17, Urbana (OH) 14 | Box score |
| Sep 02, 2010 | Clarion, Pa. | Fairmont State 27, Clarion (PA) 16 | Box score |
| Sep 02, 2010 | Glenville, WV | Glenville State 44, W.Va. Tech 10 | Box score |
| Aug 28, 2010 | Buckhannon, WV | W.Va. Wesleyan 35, Saint Paul's (VA) 28 | Box score |
| Aug 28, 2010 | Greeneville, Tenn. | Tusculum (TN) 24, Charleston 12 | Box score |
| Aug 28, 2010 | Greensburg, PA | Seton Hill 20, Bowie State (MD) 14 | Box score |
| Aug 28, 2010 | Shippensburg, PA | Shepherd 35, Shippensburg (PA) 27 | Box score |
| Aug 26, 2010 | Athens, WV | Concord 72, Southern Virginia 21 | Box score |